The study aims to optimize individualized treatment of anti-infective drugs in osteoarticular infections by analyzing drug exposure in patients blood and/or tissues using population pharmacokinetics.
Study Type
OBSERVATIONAL
Enrollment
300
Anti-infective drugs are administered using the traditional clinical dosing regimen, with no interventions.
Shandong Public Health Clinical Center
Jinan, China
RECRUITINGClearance (L/h)
Time frame: Through study completion, an average of 30 days
Volume of Distribution (L)
Time frame: Through study completion, an average of 30 days
ratio of the area under the concentration-time curve from 0 to 24 hours
For time-dependent antimicrobials, the PD target is defined as the time of free drug concentration beyond MIC during the dose interval. For concentration-dependent antimicrobials, the PD target is defined as the ratio of the area under the concentration-time curve from 0 to 24 hours to the MIC.
Time frame: Through study completion, an average of 30 days
erythrocyte sedimentation rate
Clinical treatment outcome
Time frame: Through study completion, an average of 30 days
Adverse events
Time frame: Through study completion, an average of 30 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.