The purpose of this study is to describe the population pharmacokinetic characteristics in patients with suspected/confirmed spinal infections who are undergoing anti-infective drug therapy, and to evaluate effectiveness and safety of these drugs.
Study Type
OBSERVATIONAL
Enrollment
300
Anti-infective drugs are administered using the traditional clinical dosing regimen, with no interventions.
Shandong Public Health Clinical Center
Jinan, China
RECRUITINGClearance (L/h)
Time frame: Through study completion, an average of 30 days
Volume of Distribution (L)
Time frame: Through study completion, an average of 30 days
the ratio of the area under the concentration-time curve from 0 to 24 hours
For time-dependent antimicrobials, the PD target is defined as the time of free drug concentration beyond MIC during the dose interval. For concentration-dependent antimicrobials, the PD target is defined as the ratio of the area under the concentration-time curve from 0 to 24 hours to the MIC.
Time frame: Through study completion, an average of 30 days
erythrocyte sedimentation rate
Clinical treatment outcome
Time frame: Through study completion, an average of 30 days
Adverse events
Time frame: Through study completion, an average of 30 days
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