The goal of this clinical trial is to learn if backup pacing at an increased rate improves hemodynamics in adults with relative bradycardia, a permanent pacemaker, and cardiogenic shock. The main question it aims to answer is: Does increasing the backup pacing rate to 100 beats per minute lead to improved cardiac index compared to a backup pacing rate of 75 beats per minute Participants who are already hospitalized in the Cardiovascular Intensive Care Unit with a permanent pacemaker and pulmonary artery catheter in place will be enrolled in this study. Participants will be exposed to each pacemaker rate in a randomized order with hemodynamics assessed after 10 minutes at each rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
25
Patients will have backup pacing programmed to A (75 bpm) and B (100 bpm), randomizing to sequence of exposure A-B or B-A
Vanderbilt University Medical Center
Nashville, Tennessee, United States
RECRUITINGCardiac Index by thermodilution
Cardiac Index measured by thermodilution (in liters per minute per meters squared)
Time frame: At baseline and 10 minutes after each rate programmed (i.e at 0, 15, and 30 minutes)
Cardiac Index by Indirect Fick
Time frame: 0, 15, 30 minutes.
Cardiac Output by thermodilution
Time frame: 0, 15, 30 minutes.
Cardiac Output by indirect fick
Time frame: 0 ,15, 30 minutes
Central Venous Pressure
Time frame: 0, 15, 30 minutes
Pulmonary Artery Systolic Pressure
Time frame: 0, 15, 30 minutes
Pulmonary Artery Diastolic Pressure
Time frame: 0, 15, 30 minutes
Pulmonary Artery Pulsitility Index
Time frame: 0, 15, 30 minutes
Right Ventricular Stroke Work Index
Time frame: 0, 15, 30 minutes
Pulmonary Artery (Mixed Venous) Blood Hemoglobin saturation
Time frame: 0, 15, 30 minutes
Cardiac Power Index (Thermodilution and indirect fick)
Time frame: 0, 15, 30 minutes
Cardiac Power Output (Thermodilution and indirect fick)
Time frame: 0, 15, 30 minutes
Systolic Blood pressure
Time frame: 0, 15, 30 minutes
Diastolic Blood Pressure
Time frame: 0, 15, 30 minutes
Mean Arterial Pressure
Time frame: 0, 15, 30 minutes
Difference in vasopressor/inotrope requirements
Time frame: 0, 15, 30 minutes
Arrhythmia events (Atrial and Ventricular)
Time frame: 0, 15, 30 minutes
Percentage of PVCs
Time frame: 0, 15, 30 minutes
Pacing percentage (Atrial, RV or Bi-V)
Time frame: 0, 15, 30 minutes
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