In the present study, a long-term cognitive follow-up of participants of the BioCog cohort (data collection period 2014 - 2019, Ethical vote No: EA2/092/14) from the Berlin study center is to be will be performed in order to record long-term cognitive sequelae (7 to 10 years after study inclusion). In addition to a medical telephone/video visit, the follow-up includes the collection of cognitive tests via web applications and questionnaires of acceptance and usability in the home environment. The study data are analysed in cooperation with the University of Bonn, University Medical Center Schleswig-Holstein and the University of Essen.
The primary research objective is the exploratory investigation of changes in cognitive test performance as well as cognitive self-care and functionality in former BioCog patients and BioCog subjects in the non-surgical comparison cohort in the long-term follow-up (7 - 10 years) compared to the baseline survey (from the BioCog main study).The primary question is operationalized in several ways: * according to the International Statistical Classification of Diseases and Related Health Problems(ICD-10) classification system * according to the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) classification system * computer-based, online and independently conducted cognitive testing using Cantab Web based testing from Cambridge Cognition * Cognitive self-care using Geriatric depression Scale item 10 * Cognitive self-care with Multifactorial Memory Questionnaire * Cognitive other-care with The Informant Questionnaire on Cognitive Decline in the Elderly questionnaire * Functionality with Activities of Daily Living (ADLs) \& Instrumental Activities of Daily Living (IADLs) questionnaire * Additionally: Quality of life with 5-level EQ-5D version (EQ-5D-5L) Evaluation by Mild Cognitive Impairment Algorithm of the University Clinic Bonn (research group Prof. Wagner). Evaluation by mild/major Neurocognitive Disorder (NCD) algorithm of Charité - University Medicine Berlin (research group Prof. Spies)
Study Type
OBSERVATIONAL
Enrollment
434
Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - University Medicine Berlin
Berlin, Germany
RECRUITINGChange in cognitive performance
The primary object of research is the explorative investigation of the change in cognitive test performance as well as cognitive self-care and functionality in the long-term follow-up (7 - 10 years) compared to the baseline survey (from the main BioCog study). It is measured with CANTAB Research Suite, CANTAB web-based testing and paper pencil tests.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Acceptance
Acceptance of the CANTAB web-based testing of Cambridge Cognition is measured with a questionnaire.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Usability
Usability of the CANTAB web-based testing of Cambridge Cognition is measured with a questionnaire.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
NUcleic acid Linked Immuno-Sandwich Assay Central Nervous System Disease Multiplex Panel
Analysis of 120 proteins.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
New diagnoses
Last doctor's letter/last findings (especially in the case of neurological/psychiatric/geriatric connections - e.g. memory consultation) for recording new diagnoses and recording the last outpatient and/or inpatient treatments.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Actual medication
Current comedication and supplements
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Charlson Comorbidity index
Comorbidity
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
History of Falls
History of falls is measured with the question: Have you had a fall event within the last year?
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Depression
Depression is measured with Geriatric Depression Scale.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Weight history
Weight history is measured by weight change in the past 3-6 months.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Malnutrition Universal Screening Tool (MUST)-Score
Add Scores together to calculate overall risk of malnutrition with the Malnutrition screening tool: Score 0 corresponds to low risk; Score 1 corresponds to medium risk; Score 2 or more corresponds to high risk.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Body mass index (BMI)
BMI is a calculated measure of a person's body weight (in kilograms) divided by the square of their height (in meters).
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
Mortality
Mortality is measured by the number of deaths.
Time frame: Participants will be followed for sequelae at 7-10 years after BioCog study inclusion
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