Resistance Exercise Volume and Hypertrophic Response Variability in Elderly

University of Sao Paulo General Hospital102 enrolled

Overview

The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

102

Conditions

Aging Muscle Hypertrophy

Interventions

Lower body resistance trainingOTHER

The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 60 years and older * not engaged in regular resistance and/or aerobic training for at least six months before the intervention Exclusion Criteria: * diagnosed type I diabetes mellitus * arrhythmia * noncontrolled hypertension * any major orthopedic musculoskeletal condition * use of any dietary supplement or drug with potential anabolic effects

Locations (1)

University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Quadriceps muscle cross-sectional area

Quadriceps muscle CSA was obtained through magnetic resonance imaging.

Time frame: 10 weeks

Secondary Outcomes

Maximum dynamic strength

Unilateral quadriceps 1-RM of both legs were assessed on a knee-extension machine

Time frame: 10 weeks

Data from ClinicalTrials.gov

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