The main purpose of this study is to assess how olomorasib gets into the blood stream and how long it takes the body to remove it when administered to participants with mild, moderate and severe impaired liver function compared to participants with normal liver function. The safety and tolerability of olomorasib will also be evaluated. The study may last up to 6 weeks for each participant including the screening period.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
46
Administered orally.
Orange County Research Center
Lake Forest, California, United States
Clinical Pharmacology of Miami
Miami, Florida, United States
Orlando Clinical Research Center
Orlando, Florida, United States
American Research Corporation at Texas Liver Institute
San Antonio, Texas, United States
Pharmacokinetics (PK): Maximum observed concentration (Cmax) of Olomorasib
PK: Cmax of Olomorasib
Time frame: Predose on Day 1 up to 96 hours postdose
PK: Area under the concentration versus time curve from time zero to infinity (AUC0-inf) of Olomorasib
PK: AUC0-inf of Olomorasib
Time frame: Predose on Day 1 up to 96 hours postdose
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.