The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
6,000
The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.
National Academy od Medical Sciences
Kathmandu, Nepal
RECRUITINGCentre of Infectious Disease Research
Lusaka, Zambia
RECRUITINGRheumatic heart disease
The primary outcome of the study will be the reduction in prevalence of rheumatic heart disease according to WHF criteria 2023 as assessed by systematic echocardiographic screening.
Time frame: The endpoint will be assessed after a minimum of 1 and a maximum of 3 years after introduction of the school nurse program.
Thomas Pilgrim Bern University Hospital, Bern, Switzerland
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.