CD7-specific CAR-T Cell in the Treatment of CD7-positive Relapsed/Refractory Hematologic Tumors

Inclusion Criteria: * Subjects with a diagnosis of relapsed/refractory hematologic malignancies that meet any of the following criteria: 1. Recurrence: peripheral blood or bone marrow blasts (proportion\>5%) after achieving complete remission after previous standard treatment regimens, or extramedullary disease, including: i) Early recurrence within 12 months; ii) Late recurrence of 12 months or more with no remission after one course of standard induction chemotherapy; iii) Relapse after autologous or allogeneic hematopoietic stem cell transplantation. 2. Refractory: complete remission is not achieved after at least two courses of standard induction therapy, or complete remission is not achieved after first-line or above salvage therapy * At the time of enrollment screening, bone marrow flow cytometry detected tumor cells as CD7 expression and/or pathological immunohistochemistry of extramedullary lesions was confirmed that tumor cells expressed CD7. * If tumor cells are detected in peripheral blood during enrollment screening, the immunophenotype of tumor cell surface at the time of flow cytometry detection should be CD4 and CD8 negative. If the surface immunophenotype of peripheral blood tumor cells is not CD4 and CD8 negative, the condition of ≤1% proportion of peripheral blood tumor cells must be met. * Subjects with the Eastern Cooperative Oncology Group (ECOG) fitness scores of 0 to 2. * Expected survival over 3 months; * Liver, kidney and cardiopulmonary functions meet the following requirements: 1. Serum creatinine ≤ 1.5× ULN； 2. Left ventricular ejection fraction (LVEF) ≥50%; 3. Baseline peripheral oxygen saturation \> 90%; 4. Total bilirubin ≤ 1.5×ULN; ALT and AST ≤2.5×ULN. * Patient or his or her legal guardian voluntarily participates in and signs an informed consent form. Exclusion Criteria: * Appearance of one of the following cardiac criteria: atrial fibrillation; myocardial infarction in the last 12 months; prolonged QT syndrome or secondary QT extension, as judged by the investigator. Echocardiography LVSF \<30% or LVEF \<50%; clinically significant pericardial effusion; cardiac insufficiency NYHA (New York Heart Association) III or IV (confirmed by echocardiography within 12 months of treatment). * Active GVHD. * History of severe pulmonary function impairment disease. * Other malignant tumors in the advanced stage. * Severe infection or persistent infection that cannot be effectively controlled. * Combined with severe autoimmune disease or innate immune deficiency. * Active hepatitis (hepatitis B virus deoxyribonucleic acid \[HBV-DNA 500 IU / ml and abnormal liver function\] or hepatitis C antibody \[HCV-Ab\] positive, HCV-RNA above the lower limit of detection of the analytical method and abnormal liver function). * Human immunodeficiency virus (HIV) infection or syphilis infection. * History of severe allergies to biological products (including antibiotics). * Central nervous system disorders, such as uncontrolled epilepsy, cerebrovascular ischemia/hemorrhage, dementia, cerebellar diseases, etc.. * Female patients are in pregnancy and lactation, or have a pregnancy plan within 12 months. * Situations where the investigator may increase the risk or interfere with the test results.