How does magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) impact clinical prognosis in mesial temporal lobe epilepsy (mTLE)?
1. Compare the clinical prognosis between magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) and traditional open surgery (OS) on patients with mesial temporal lobe epilepsy (mTLE). 2. Explore the factors associated with seizure outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
MRgLITT employs laser energy delivered through a stereotactically placed laser applicator to precisely ablate the epileptogenic tissue.
Traditional Open Surgery
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
RECRUITINGSeizure freedom rate
According to International League Against Epilepsy \[ILAE\] Outcome Scale
Time frame: 6-month, 1-year after surgery
Seizure frequency
Times/Months
Time frame: 6-month, 1-year after surgery
Seizure severity
National Hospital Seizure Severity Scale (NHS3)
Time frame: 6-month, 1-year after surgery
Cognitive function evaluation
Multiple Ability Self-Report Questionnaire (MASQ)
Time frame: 6-month, 1-year after surgery
Memory function evaluation
Multifactorial Memory Questionnaire (MMQ)
Time frame: 6-month, 1-year after surgery
Quality of life for epilepsy patients
EQ-5D-5L
Time frame: 6-month, 1-year after surgery
Adverse events
percentage
Time frame: within 7 days, 6-month, 1-year after surgery
Severe adverse events
percentage
Time frame: within 7 days, 6-month, 1-year after surgery
Length of hospital stay
days
Time frame: after surgery
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Rate of antiepileptic drug reduction or withdrawn
percentage
Time frame: 1-year after surgery
Rate of reoperations
percentage
Time frame: 1-year after surgery