Multiple Sclerosis (MS) is the second most common neurological disorder in young adults after trauma. Treatments developed today can slow progression and reduce symptoms. Exercise therapy is a useful rehabilitation practice in MS to manage symptoms, restore function, optimize quality of life, ensure well-being and increase participation in daily life activities. In this study, it is planned to investigate the acute effects of conservative and virtual reality (VR)-based aerobic exercise applications and standard exercises that frequently form the rehabilitation programs of individuals with MS in clinics. For this purpose, patients with MS who met the inclusion criteria were given two-week intervals; Conservative aerobic exercise, virtual reality-based aerobic exercise and standard exercise practices will be performed. With the data obtained from this study, it is aimed to investigate the safety of aerobic exercises performed using VR tools that can be used in telerehabilitation applications, which are thought to have a very important place in MS rehabilitation in the future, in terms of acute body temperature increase, cognitive and physical fatigue caused by conservative methods and fNIRS cortical effects of VR-based aerobic exercise applications. It will be possible to prove it with objective methods such as.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
12
Traditional aerobic exercise will be continued with an arm ergometer, at moderate intensity, for 30 minutes.
In the virtual reality-based aerobic exercise training, the game called "Beat Saber" will be played with Oculus Quest 2 virtual reality for 30 minutes.
The conventional exercise program will be modified with stabilization, balance and strengthening exercises, taking into account the functional status of the participants.
Acibadem University
Ataşehir, Istanbul, Turkey (Türkiye)
Energy Spent
Sense Wear Pro3 Armband by Body Media Inc. (USA): It will be used to calculate the energy spent during exercises. This device is a 2-axis monitor with multiple sensors such as a galvanic skin response sensor to evaluate skin electrical resistance changes and a skin temperature sensor to evaluate temperature changes. The device will be worn on the individuals' right arm triceps muscle throughout the exercises and will be used to calculate the energy spent during the exercises.
Time frame: For 30 minutes during the entire exercise
Cortical Activity
Functional Near Infrared Light Spectroscopy (fNIRS): fNIRS is an optical system that uses near-infrared (NIR) light in the assessment of brain activity by measuring light absorption differences in changes in oxy-hemoglobin and deoxy-hemoglobin concentrations. The modified Beer-Lambert law is used to convert and calculate light intensity measurements obtained from the brain into hemodynamic changes. Hemodynamic responses that occur with different stimuli in the prefrontal cortex region of the brain can be monitored with these optical systems. In this study, it is planned to measure individuals' prefrontal cortex activations while performing 3 different exercises and a post-exercise cognitive performance test.
Time frame: During preintervention cognitive tasks, for 30 minutes during the entire exercise, during postintervention cognitive tasks
Body Temperature
Individuals' body temperatures will be measured with the help of an electronic digital thermometer before and after the exercises.
Time frame: immediately before the exercise, immediately after the exercise
Electrodermal Activity
Electrodermal activity data will be recorded with the Shimmer device to be used to determine the stress levels of the patients.
Time frame: During preintervention cognitive tasks, for 30 minutes during the entire exercise, during postintervention cognitive tasks
Cognitive Function
Stroop test will be used to compare the cognitive performances of the patients before and after exercise and to comment on cognitive fatigue after exercise.
Time frame: Immediately before the exercise, immediately after the exercise
Cognitive Function
2-back test will be used to compare the cognitive performances of the patients before and after exercise and to comment on cognitive fatigue after exercise.
Time frame: Immediately before the exercise, immediately after the exercise
Cognitive Function
Symbol Digit Modalities Test will be used after the exercise to evaluate cognitive performance.
Time frame: Immediately after the exercise
Physical Fatigue
Modified Borg Scale will be used after the exercise to evaluate subjective physical fatigue. The values of this scale range from 0 to 10. While 0 means I have no fatigue, 10 indicates the most severe fatigue.
Time frame: Immediately after the exercise
Satisfaction Level satisfaction level Satisfaction Level
It will be evaluated with the Satisfaction Evaluation Survey of Virtual Rehabilitation Systems. The total score range in this survey varies between 6-30, with higher scores being associated with higher satisfaction.
Time frame: Immediately after the exercise
Late-term fatigue
One day after the exercises, patients will be questioned by phone about whether they have arm pain, and in case of pain, they will be asked to score the severity of pain according to Modified Borg Scale. The values of this scale range from 0 to 10. While 0 means I have no fatigue, 10 indicates the most severe fatigue.
Time frame: 24 hours later after the exercise
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