Stingless Bee Honey Augmentation in Major Depressive Disorders

Hospital Universiti Sains Malaysia45 enrolled

Overview

The goal of this clinical trial is to learn if stingless bee honey can be an augmentation supplement in Major Depressive Disorder (MDD) in adults. It will also learn about the adverse effects of the honey. The main questions it aims to answer are: 1. Is there any effect of SBH on depressive symptoms between intervention and control groups in MDD? 2. Are there any effects of SBH on BDNF between intervention and control groups in MDD? 3. Are there any effects of SBH on oxidative stress between intervention and control groups in MDD? 4. Are there any effects of SBH on verbal learning and memory between intervention and control groups in MDD? There is no placebo. Participants will: Take stingless bee honey or nothing every day for 2 months Visit the clinic once every 4 weeks for checkups and tests Report adherence and adverse effects of stingless bee honey on a self-reported online questionnaires

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Major Depressive Disorder (MDD)

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults with ages 18 to 65 * with Major Depressive Disorder with scores of Beck Depression Inventory Malay version equal or more than 11 Exclusion Criteria: * Women in pregnancy or breast-feeding. * Patients who with honey allergy or stingless bee honey allergy. * Currently taking honey not limited to stingless bee honey or taken honey not limited to stingless bee honey in the past one month. * comorbidity either with generalized anxiety disorder, * panic disorder, * social anxiety disorder, * bipolar disorder, * substance-use disorder, * suicidal ideation or attempt, * dementia, * Alzheimer disease, * diabetic, * hypertension, * chronic kidney disease

Outcomes

Primary Outcomes

Depressive symptoms

Depressive symptoms will be assessed using Beck Depression Inventory Malay-version questionnaire, For total score, no depression (1 - 10); mild to moderate (11 -20); moderate to severe (21 - 30); severe (31 - 40); very severe (41 - 63).