Ultrasound Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients

Inclusion Criteria: \- The subject selection was according to the following criteria: * Adults their ages ranged from 20 to 70 years old. * Receiving or have received chemotherapy treatment for colon or rectal cancer. * Chemotherapy regimen included the agent oxaliplatin. * Patients diagnosed with neuropathy by the oncologist. * Both sexes. * No neuropathy prior to oxaliplatin treatment. * No documented or observable psychiatric or neurological disorders that would interfere with study participation (eg, dementia or psychosis) * Stage II, III and IV colon or rectal cancer. * Hands and Feets were the most affected by CIPN. * The first dose of oxaliplatin was from 4 months or more. Exclusion Criteria: * The potential participants were excluded in the following conditions: * Another malignancy * Patients with severe or unstable cardiorespiratory or musculoskeletal diseases that may influence the accuracy of quantitative sensory testing results. * Participants who cannot remain on the same medications throughout the study period with minor dose adjustments allowed. * Contraindications to therapeutic ultrasound including active cancer in region of hands or feet, presence of deep vein thrombosis, complete numbness in hands or feet (representing severe CIPN), metal or plastic implantation * Peripheral vascular disease in hands or feet.