Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes

Inclusion Criteria: 1. Men and women between the ages of 18 and 75 years old, inclusive, at the time of screening; 2. Females of non-childbearing potential must be ≥ 1 year post-menopausal or documented as being surgically sterile. Females of childbearing potential must agree to use two methods of contraception during the entire study; 3. Diagnosed with Type 1 diabetes \>2-year duration based on clinical history or as defined by the current American Diabetes Association (ADA) criteria; 4. Using hybrid closed loop, standard pump, or multiple daily injections; 5. Able to use a Continuous Glucose Monitoring (CGM) device; 6. A1c \> 7% and ≤ 10%: 7. eGFR ≥ 60 mL/min/1.73m²; 8. BMI 18.5-35.0 kg/m2 ; 9. Able to provide written informed consent approved by an Institutional Review Board (IRB). Exclusion Criteria: 1. History or evidence of clinically significant disorder or condition that, in the opinion of the Investigator, would pose a risk to subject safety or interfere with the study evaluation, procedures, or completion; 2. History of pancreatitis, medullary thyroid carcinoma or liver disease: 3. Clinically significant diagnosis of anemia (Hemoglobin \< 9 g/dl at screening); 4. Body Mass Index (BMI) \< 18.5 kg/m2 and/or weight \<50kg; 5. Body Mass Index (BMI) \> 35 kg/m2; 6. Whole blood donation of 1 pint (500 mL) within 8 weeks prior to Screening. Donations of plasma, packed RBCs, platelets or quantities less than 500 mL are allowed at investigator discretion; 7. Current or recent (within 1 month of screening) use of diabetes medications other than insulin; (examples include GLP-1, RA, SGLT-2i, Pramlintide, Metformin); 8. Women who are pregnant or lactating/breastfeeding; 9. Unable or unwilling to follow the study protocol or who are non-compliant with screening appointments or study visits; 10. Any other condition(s) that might reduce the chance of obtaining study data, or that might cause safety concerns, or that might compromise the ability to give truly informed consent; 11. Severe hypoglycemic events or DKA within 3 months; 12. Currently using beta-blockers; 13. Adrenal insufficiency diagnosis.