The Future Management of Patients With Neoplasms of the Gastro-intestinal Tract

N/AActive Not RecruitingNCT06728358

Fondazione Policlinico Universitario Agostino Gemelli IRCCS300 enrolled

Overview

The aim of the present study is to research histological and molecular markers in patients with neoplasia of the gastrointestinal tract.

The aim of the present study is to search for histological and molecular markers in patients with neoplasia of the gastrointestinal tract.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

300

Conditions

Pancreatic Adenocarcinoma Cholangiocarcinoma Colon Cancer

Interventions

Molecular analysesDIAGNOSTIC_TEST

Search for molecular alterations that correlate with patient prognosis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 years or older; * PS ECOG 0-2; * Histological diagnosis of cancer of the gastro-enteric district: intestinal, pancreatic, biliary tract neoplasms; * Radiological evidence of resectable/locally advanced/metastatic disease on the date of the first visit; * Availability of tumour histological material; * At least one visit following the first oncological visit. Exclusion Criteria: * Absence of histological diagnosis of neoplasm of the gastro-enteric tract; * Lack of histological specimens on which to perform examinations.

Locations (1)

Policlinico Universitario Agostino Gemelli

Rome, Lazio, Italy

Outcomes

Primary Outcomes

Overall Survival

The primary objective of the study is to evaluate the probabilitỳ of survival in terms of OS in relation to the expression of specific anatomopathological, immunohistochemical and molecular markers (GATA6, GemPred Molecular Signature and FOLFIRINOX Molecular Signature) present in the tumour tissue of patients with neoplasms of the gastro-enteric district in the setting of resectable/metastatic disease.

Time frame: 48 months

Data from ClinicalTrials.gov

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