Expanded Access to CD34+ Selection Utilizing Miltenyi CliniMACS Prodigy® for Patients Receiving Peripheral Blood Stem Cell Transplantations and Stem Cell Boosts

Inclusion Criteria: * Patients over 1 month of age * The following category of patients is eligible for this protocol: a. Patients undergoing allogeneic transplantation for the following indications: i. Non-malignant disorders where graft versus host disease is detrimental: * Severe combined immune deficiency * Fanconi Anemia * Dyskeratosis Congenita * Sickle Cell Disease or b. Patients undergoing autologous transplantation intended for hematopoietic/immunologic reconstitution or c. Patients with poor graft function defined as persistent cytopenia following stem cell transplant without evidence of recurrent disease * Subjects must not have more than one active malignancy at the time of enrollment (Subjects with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen \[as determined by the treating physician and approved by the PI\] may be included). * Written informed consent obtained from the subject and the subject agrees to comply with all the study-related procedures. * Women of childbearing potential (WOCBP) must be using an adequate method of contraception to avoid pregnancy throughout participation at least 1 year after the stem cell infusion to minimize the risk of pregnancy. Prior to protocol enrollment, women of childbearing potential must be advised of the importance of avoiding pregnancy during trial participation and the potential risk factors for an unintentional pregnancy. WOCBP includes any woman who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or who is not post-menopausal. Post-menopause is defined as: 1. Amenorrhea that has lasted for ≥ 12 consecutive months without another cause, or 2. For women with irregular menstrual periods who are taking hormone replacement therapy (HRT), a documented serum follicle-stimulating hormone (FSH) level of greater than 35 mIU/mL. * Males with female partners of child-bearing potential must agree to use physician-approved contraceptive methods (e.g., abstinence, condoms, vasectomy) throughout participation and should avoid conceiving children for 1 year following infusion of the stem cells. Exclusion Criteria: * Patients with a fully HLA matched sibling donor * Patients with active graft versus host disease * Patient with uncontrollable transplant associated thrombotic microangiopathy * Patient not cleared by transplant provider to process * Donor unable to donate peripheral blood stem cells * Females or males of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire participation period and for at least 1 year after stem cell infusion. * Females who are known to be pregnant or breastfeeding. * Prisoners or subjects who are involuntarily incarcerated, or subjects who are compulsorily detained for treatment of either a psychiatric or physical illness.