This is a single-arm, open-label, single-center, phase I study. The primary objective is to evaluate the safety of CD7 Chimeric Antigen Receptor-T(CAR-T) therapy for patients with CD7-positive relapsed or refractory natural killer/T cell lymphoma, and to evaluate the pharmacokinetics of CD7 CAR-T in patients。
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
CAR-T cells
Union Hospital
Wuhan, Hubei, China
RECRUITINGOverall response rate (ORR)
The proportion of patients with complete response (CR) /complete response with incomplete blood cell recovery (CRi)
Time frame: Evaluate at 4 weeks after CAR-T infusion
Duration of remission (DOR)
The time from CR/CRi and PR to disease relapsed or death due to disease progression after CAR-T infusion
Time frame: Up to 1 years after CAR-T infusion
Event-free survival (EFS)
The time from first achieving CR/CRi to relapse or death
Time frame: Up to 1 years after CAR-T infusion
Overall survival (OS)
The time from CAR-T infusion to death due to any cause
Time frame: Up to 1 years after CAR-T infusion
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