Strenght Training in Osteoporosis Prevention

N/AActive Not RecruitingNCT06733064

Mateusz Karnia120 enrolled

Overview

The study involves 120 women over the age of 50. All participants in the study take part in high-intensity strength training for 10 months. In addition, half of the participants receive vitamin D3 at a dose of 4,000 IU/day. The investigators hypothesize that training combined with vitamin D3 supplementation will be more effective in preventing osteoporosis than training alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

120

Conditions

Osteopenia or Osteoporosis

Interventions

Supplementation of vitamin D3DIETARY_SUPPLEMENT

Supplementation of vitamin d3 at a dose of 4000 iu / day

PlaceboDIETARY_SUPPLEMENT

Vegetable oil as a placebo

Eligibility

Sex: FEMALEMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age over 50 * female Exclusion Criteria: * ongoing cancer, * unstabilized cardiovascular disease, * cognitive disorders, * radiological treatment in the last 12 months, * other contraindications to undertaking high-intensity strength training, * diseases affecting the skeleton such as: Paget's disease, type I diabetes mellitus, * taking medications affecting skeletal conditions including: long-term therapy with corticosteroids, thiazides, antiretroviral drugs, * contraindications to taking vitamin D including: hypercalcemia, nephrolithiasis, sarcoidosis, lack of cholecalciferol hydroxylase activity in the liver and kidneys.

Locations (2)

University of Gdańsk, Faculty of Biology

Gdansk, Pomeranian Voivodeship, Poland

University of Gdańsk, Faculty of Biology

Gdansk, Poland

Outcomes

Primary Outcomes

Bone Mineral Density

Test to determine bone mineral density by densitometry.

Time frame: Measured at 3 time points: before the experiment, after 10 months of training, and at 6 months after the end of training and supplementation.

Secondary Outcomes

Vitamin D metabolites level

Measurement evaluating the levels of selected vitamin D3 metabolites by LC-MS.

Time frame: Measured at 4 time points: before the experiment, after 5 and 10 months of training, and at 6 months after the end of training and supplementation.

Data from ClinicalTrials.gov

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