This study examines whether adding tirzepatide-a medication that helps with weight loss-after sleeve gastrectomy surgery can help people lose more weight after the surgery; better improve conditions like Type 2 diabetes, high blood pressure, high cholesterol, and sleep apnea after surgery and; whether this causes more complications or side effects compared to surgery alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
42
In this study, the intervention group (n=21) are patients who will undergo sleeve gastrectomy and receive tirzepatide after surgery. Patients who were selected in this arm will undergo a 4-week dose escalation period. Starting at 6 months they will receive weekly 2.5mg doses (for 4 weeks). Afterwards, they will receive weekly 5mg doses. They will maintain this dose until 12 months after surgery.
Subjects in both the interventional group (n=21) and the control group (n=21) will undergo sleeve gastrectomy.
Rush University Medical Center
Chicago, Illinois, United States
RECRUITINGWeight Loss
Time frame: 12 months after surgery
Weight Loss
Time frame: 18 months after surgery
Type 2 Diabetes
Researchers will use Hemoglobin A1c (%) to measure Type 2 Diabetes. A lower value indicates improvement.
Time frame: 12 months after surgery
Type 2 Diabetes
Researchers will use Hemoglobin A1c (%) to measure Type 2 Diabetes. A lower value indicates improvement.
Time frame: 18 months after surgery
High Blood Pressure
Time frame: 12 months after surgery
High Blood Pressure
Time frame: 18 months after surgery
High Cholesterol
Researchers will measure Cholesterol by the number of cholesterol-lowering medications needed by the subject (#). A lower value indicates improvement.
Time frame: 12 months after surgery
High Cholesterol
Researchers will measure Cholesterol by the number of cholesterol-lowering medications needed by the subject (#). A lower value indicates improvement.
Time frame: 18 months after surgery
Sleep Apnea
Researchers will measure Sleep Apnea by subject's need for a CPAP (continuous positive airway pressure) machine (Y/N).
Time frame: 12 months after surgery
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Sleep Apnea
Researchers will measure Sleep Apnea by subject's need for a CPAP (continuous positive airway pressure) machine (Y/N)
Time frame: 18 months after surgery
Complications/Side Effects
Time frame: 12 months after surgery
Complications/Side Effects
Time frame: 18 months after surgery