The goal of this clinical trial study is to evaluate the impact of a personalized lifestyle intervention on improving healthspan. The primary questions of interest are whether the personalized intervention will result in improvements in muscle function, immune function, and cognitive function in adults aged 50-85 years. Participants will complete baseline assessments, receive an individualized intervention plan for approximately 3 months, and then complete post-intervention assessments. The intervention includes an exercise plan, nutrition recommendations, and general lifestyle goals that will be personalized to each participant.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
25
Each subject will receive a personalized intervention plan, comprised of: 1. An individualized exercise plan guided by a mobile phone app. 2. Healthy diet and nutrition recommendations. 3. Theriome metabolomics testing and individualized recommendations that include dietary supplements. 4. Guidance on healthy sleep patterns, stress management, and maximizing social engagement, as appropriate.
Wexford Innovation Center
Phoenix, Arizona, United States
VO2 max
A maximal treadmill exercise test with respiratory gas exchange analysis to assess cardiorespiratory fitness.
Time frame: From baseline to the end of the intervention at 3 months.
Biodex
A Biodex will be used to assess leg muscle power and strength.
Time frame: From baseline to the end of the intervention at 3 months.
World Health Organization Quality of Life Survey
We will assess quality of life with the WHO\_QoL. The WHO\_QoL is scored from 0-100 with a higher score indicating a higher quality of life.
Time frame: From baseline to the end of the intervention at 3 months.
Pittsburgh Sleep Quality Index
This questionnaire assesses sleep quality. The PSQI is scored on a scale from 0-21 with a higher score indicating higher sleep quality.
Time frame: From baseline to the end of the intervention at 3 months.
Handgrip strength
A hand-held dynamometer will be used to measure handgrip strength.
Time frame: From baseline to the end of the intervention at 3 months.
Dual Energy X-ray Absorptiometry (DXA)
A DXA scan will be used to assess body composition and bone mineral density.
Time frame: From baseline to the end of the intervention at 3 months.
Waist circumference
Waist circumference will be measured at the superior border of the iliac crest.
Time frame: From baseline to the end of the intervention at 3 months.
Hip circumference
Hip circumference will be measured at the maximal protrusion of the buttocks.
Time frame: From baseline to the end of the intervention at 3 months.
Systolic blood pressure
Systolic blood pressure will be measured at rest.
Time frame: From baseline to the end of the intervention at 3 months.
Diastolic blood pressure
Diastolic blood pressure will be measured at rest.
Time frame: From baseline to the end of the intervention at 3 months.
Digit Symbol Substitution Test (DSST)
The DSST assesses cognition and cognitive impairment.
Time frame: From baseline to the end of the intervention at 3 months.
Montreal Cognitive Assessment (MoCA)
The MoCA assesses cognition and cognitive impairment. The MoCA is scored out of 30 points and a higher score indicates better cognitive function.
Time frame: From baseline to the end of the intervention at 3 months.
Short Physical Performance Battery
A performance test to assess balance and physical function.
Time frame: From baseline to the end of the intervention at 3 months.
Low Density Lipoprotein Cholesterol
A test assessing calculated LDL cholesterol.
Time frame: From baseline to the end of the intervention at 3 months.
Hemoglobin A1C Concentration
This will assess a participants HbA1C.
Time frame: From baseline to the end of the intervention at 3 months.
Insulin Concentration
This test will assess a participants fasting insulin.
Time frame: From baseline to the end of the intervention at 3 months.
Geriatric Depression Scale (GDS)
This survey assesses feelings of depression in older adults. The GDS is scored from 0-15, with a higher score indicating more feelings of depression.
Time frame: From baseline to the end of the intervention at 3 months.
Generalized Anxiety Disorder (GAD)-7
This survey assess feelings of anxiety. The GAD-7 is scored from 0-21, with higher scores indicating higher feelings of anxiety.
Time frame: From baseline to the end of the intervention at 3 months.
Perceived Stress Scale
This survey assesses perceived stress. This survey is scored from 0-40 with higher scores indicating higher stress.
Time frame: From baseline to the end of the intervention at 3 months.
High Density Lipoprotein Cholesterol
A blood test measuring HDL cholesterol.
Time frame: From baseline to the end of the intervention at 3 months.
Brief Resilience Scale
This survey assess a participants resilience. This survey is scored from 0-30 with higher scores indicating a higher level of resilience.
Time frame: From baseline to the end of the intervention at 3 months.
Non-High Density Lipoprotein Cholesterol
A blood test measuring non-HDL cholesterol.
Time frame: From baseline to the end of the intervention at 3 months.
Very Low Density Lipoprotein Cholesterol
A blood test measuring VLDL cholesterol.
Time frame: From baseline to the end of the intervention at 3 months.
CD3 T cells
This test will measure how many CD3 Mature T Cells are in the blood. This will be reported as a percentage.
Time frame: From baseline to the end of the intervention at 3 months.
CD4 T cells
This test will measure the CD4 T cells in the blood. This will be reported as a percentage.
Time frame: From baseline to the end of the intervention at 3 months.
CD8 T cells
This test will measure the CD8 T cells in the blood. This will be reported as a percentage.
Time frame: From baseline to the end of the intervention at 3 months.
Natural Killer cells
This test will measure the NK cells in the blood. This will be reported as a percentage.
Time frame: From baseline to the end of the intervention at 3 months.
B cells
This test will measure the B cells in the blood. This will be reported as a percentage.
Time frame: From baseline to the end of the intervention at 3 months.
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