Question: How effective is fortified iodized salt with folic acid (FISFA) in increasing serum and red blood cell folate in non-lactating, non-pregnant women of reproductive age in the country of Zambia who do not have active food fortification with a folic acid program? Participants will: * Consume salt with folic acid instead of their regular salt for 6 months * Have a blood draw 4 times * Fill out surveys
The objective of this nonrandomized controlled intervention trial is to measure the effectiveness of fortified iodized salt with folic acid (FISFA) on increasing blood folate concentrations as a preventive measure against folate-sensitive neural tube defects (NTDs) in a non-fortifying country of Zambia. The main questions it aims to answer are: Aim 1: Measure the effectiveness of FISFA on increasing serum and red blood cell folate concentrations in women of reproductive age in a non-fortifying country. Aim 2: Assess the risk of neural tube defects by measuring folate insufficiency levels via serum and red blood cell concentrations in women of reproductive age in a non-fortifying country. Aim 3: Assess taste and color acceptability of FISFA by study population.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
250
Addition of folic acid to iodized salt for daily consumption to assess folate levels.
University of Alabama at Birmingham
Birmingham, Alabama, United States
Centre for Infectious Disease Research in Zambia
Lusaka, Zambia
Measure change in median and mean serum folate levels between baseline, month 1, month 3 and month 6 (endpoint)
Evaluate folate blood levels pre and post intervention
Time frame: 0-6 months
Measure change in median and mean red blood cell folate levels between baseline, month 1, month 3 and month 6 (endpoint)
Evaluate folate blood levels pre and post intervention
Time frame: 0-6 months
Descriptive analysis of acceptability of FISFA by participants (taste and color on Likert scale)
Evaluate salt with folic acid acceptability using Likert scale (1-5, with 5 being the better outcome)
Time frame: 1,3,6 months
Measure of folate insufficiency via serum and RBC concentration
Comparing folate insufficiency via serum and RBC concentration to recommended levels of 25.5 nmol/L (serum) and 906 nmol/L in RBC for WRA
Time frame: 0-6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.