Protein, Sarcopenic Obesity, and COPD

University of Aberdeen13 enrolled

Overview

Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults. Previous research has shown that increased dietary intake of total and plant-based protein is associated with a lower risk of sarcopenic obesity, using data from the EPIC Norfolk study. Furthermore, a systematic review and meta-analysis showed that having sarcopenic obesity was associated with significantly impaired lung function outcomes. Other research has shown that increased intake of dietary protein leads to a better treatment outcome for respiratory diseases. The aim of this pilot observational study is to investigate, in more detail, the relationship between the quantity and source of dietary protein intake, the prevalence of sarcopenic obesity, and lung function, in a small cohort of older female participants with COPD. The study will also consider the role of inflammation in relation to sarcopenic obesity and lung function outcomes. This study will help to improve the understanding of the relationship between sarcopenic obesity and lung function outcomes, and how dietary protein intake and inflammation can affect this relationship and each of the outcomes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcopenic Obesity Chronic Obstructive Pulmonary Diseases

Interventions

Primary Objective The primary objective is to measure the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes, in older female participants with clinically diagnosed COPD. Secondary Objectives The secondary objective is to investigate whether the level of inflammation (plasma CRP) is associated with the intake of total, plant-based and animal-based protein, with the prevalence of sarcopenic obesity, and with lung function outcomes.

Eligibility

Sex: FEMALEMin age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women. * Clinically diagnosed with COPD. * Aged 55 years or older. Exclusion Criteria: * Male. * Women who are 54 years or younger. * Those who have dementia. * Unable to read or write in English. * Unable to attend the Human Intervention Studies Unit. * Those within one year life expectancy. * Those who have cancer.

Outcomes

Primary Outcomes

Association between dietary protein and the prevalence of sarcopenic obesity

Association between dietary intake of total, plant-based and animal-based protein and the prevalence of sarcopenic obesity.

Time frame: through study completion, an average of 1 year

Secondary Outcomes

Association between dietary protein and lung functions outcomes

Association between dietary intake of total, plant-based and animal-based protein and lung functions outcomes (Forced Vital Capacity (FVC), Forced Expiratory Volume in The First Second(FEV1), and The Ratio of Forced Expiratory Volume in The First Second to Forced Vital Capacity (FEV1/FVC ratio)).