Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Inclusion Criteria: * age \>18 years * History of MASLD, with liver fat content \> 5% * Normal kidney function * Stable medication for at least 1 month for diabetes mellitus if any * Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits Exclusion Criteria: * Age \< 18 years * Inaccurate 24-hour urine collections * Liver fat content \<5% * Liver cirrhosis * Evidence of other chronic liver disease, viral hepatitis * history of alcoholism within 2 years of enrollment * Contra-indication to Magnetic Resonance Imaging * Chronic kidney disease with estimated Glomerular Filtration rate \< 60 ml/min/1.73m2 * Type 1 Diabetes Mellitus or treatment with insulin * Uncontrolled diabetes * Pregnancy, lactation or intention to be * Uncontrolled hypertension * Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID * History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption * Chronic fat malabsorption * Use of immunosuppressive medications * Known immuno-compromised status * Active malignancy or treatment for malignanacy within the last 12 months