Correlation of Preoperative Indices (serum Vit D, Calcium, Phosphorus, FAR, PLR, SII) on Intraoperative Bleeding in CRS

N/AActive Not RecruitingNCT06737198

Nanjing First Hospital, Nanjing Medical University100 enrolled

Overview

The purpose of this observational study was to examine whether preoperative indicators correlate with intraoperative bleeding to facilitate control of intraoperative bleeding.

In this study, we analysed the effect of preoperative inflammation on intraoperative haemorrhage at the subjective and objective levels by measuring a number of indicators (including Vit D, Ca, P, and some ratios) in the blood specimens and by three scales.Blood test indicators can be obtained from routine tests.Three scales were obtained by the researcher after interviewing the patients, Symptom Score (0-15), where higher scores indicate more severe symptoms, Lund-Kennedy Score (0-6), where higher scores indicate higher levels of localised inflammation, Lund-Mackay Score (0-12 unilaterally and 24 bilaterally), where higher scores indicate higher levels of inflammation, and Lund-Mackay Score (0-12 unilaterally and 24 bilaterally), where higher scores indicate higher levels of inflammation.Lund-Mackay score (0-12 unilaterally, 24 bilaterally), where higher scores represent higher levels of inflammation.Final correlation of blood test indices and three scale scores with intraoperative.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Chronic Rhinosinusitis (CRS) with and Without Nasal Polyps

Interventions

without interventios.OTHER

without interventios.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Clinical diagnosis of chronic rhinosinusitis Exclusion Criteria: Sinus cyst Upper respiratory tract infection in the last 1 week Use of antiepileptic drugs Use of aspirin Use of anticoagulant or antiplatelet drugs

Locations (1)

Nanjing First Hospital

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

Intraoperative haemorrhage

Intraoperative haemorrhage was grouped with a cut-off value of 150 ml and divided into \<150 ml (normal haemorrhage group) and ≥150 ml (high haemorrhage group).

Time frame: 2024/11/1-2025/7/31

Secondary Outcomes

Symptom system

Symptom system (0-15 scores), assessed in five areas: nasal congestion, runny nose, reduced sense of smell, head and face swelling, and sleep disturbances, where higher scores represent more severe symptoms.

Time frame: 2024/11/1-2025/7/31

Lund-Kennedy system

Lund-Kennedy system (0-6 scores), assessed under nasal endoscopy in terms of polyps, oedema and nasal secretions, where a higher score represents a higher level of local inflammation.

Time frame: 2024/11/1-2025/7/31

Lund-Mackay system

The Lund-Mackay system (0-12 unilaterally, 24 points in total bilaterally) analyses the inflammatory status within each sinus and the assessment of whether the sinonasal complex is obstructed in two major ways, where higher scores represent higher levels of inflammation.

Time frame: 2024/11/1-2025/7/31

Data from ClinicalTrials.gov

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