In this study, we aim at assessing the benefits of dietary supplementation with ABB i5 and ABB C24, a combination of the the prebiotic ABB i5 and the postbiotic ABB C22, on the gut microbiota of people with constipation and on their gastrointestinal well-being.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
34
Isabel Roig
Barcelona, Barcelona, South Sudan
Microbiota composition
Changes in microbiota composition through Shanon diversity test and statistical analyses (Continuous variables will be described as mean and standard deviation (SD) or as median and interquartile range; and categorical variables such as absolute frequencies and percentages).
Time frame: from baseline to day 14 of supplementation
Transit time
transit time measured as methane on breathe testing
Time frame: from baseline to day 14 of supplementation
Tolerance and gastro-intestinal comfort
Tolerance and gastro-intestinal comfort (validated questionnaires) life questionnaire: the Digestion-associated Quality of Life Questionnaire (DQLQ)
Time frame: from baseline to day 14 of supplementation
Brain Derived Neurotrophic Factor (BDNF)
levels of Brain Derived Neurotrophic Factor (BDNF) (pg/mL)
Time frame: from baseline to day 14 of supplementation
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