Thyroid Dysfunction and Its Association With Metabolic Dysfunction-Associated Fatty Liver Disease

Tanta University150 enrolled

Overview

This study aims to evaluate the prevalence of thyroid dysfunction and its association with metabolic dysfunction-associated fatty liver disease.

One of the most common causes of chronic liver diseases worldwide is metabolic dysfunction-associated fatty liver disease (MAFLD), which affects about 30% of adults. Thyroid hormones are critical in maintaining metabolic homeostasis throughout life and are intimately linked to the liver. Dysfunctions of the thyroid gland have been implicated as one of the most important risk factors of MAFLD due to its important role in the hepatic synthesis of fatty acid and cholesterol. Maintaining liver metabolism requires thyroid function to be normal, while thyroid disorders may lead to liver disease progression.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Thyroid Dysfunction Metabolic Dysfunction-Associated Fatty Liver Disease

Interventions

FibroscanDEVICE

Fibroscan will be used to assess the stages of fibrosis and steatosis using Dimensional ultrasound TE (transient elastography). Dimensional ultrasound TE (transient elastography) will be used for staging liver fibrosis and steatosis by measuring the velocity of a low frequency (50 Hz) elastic shear wave propagating through the liver.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years. * Both sexes. * Patients with metabolic dysfunction-associated fatty liver disease (MAFLD). Exclusion Criteria: * History of thyroid disease or treatment (e.g., thyroid nodules, thyroid cancer, hypothyroidism, and hyperthyroidism). * Patients with alcoholic liver disease take more than 40g of alcohol (or four units) per day. * Viral hepatitis. * Pregnant women.

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt

RECRUITING