The goal of this clinical trial is to test if a Lingzhi supplement (CP003) helps people with chronic fatigue or post-COVID fatigue feel better. It will also check if the supplement is safe to use. The main questions it aims to answer are: Does the Lingzhi supplement reduce fatigue symptoms? Is it safe to take? How does it affect the body's immune system and inflammation? The investigators will compare people taking the Lingzhi supplement to those who do not receive any treatment (waitlist group) to see if it works. Participants will: * Take 5 capsules once daily for 6 weeks (or wait to start treatment if in waitlist group) * Visit the clinic 2 times for blood tests (before and after taking the supplement) * Complete questionnaires 3 times about their fatigue and quality of life (4 times participants in the waitlist group)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
130
Lingzhi-containing capsules (CP003) is a Chinese Medicine nutritional supplement manufactured by Chinese Pharm Co., Ltd, containing: wild red ganoderma extract, ganoderma spore powder (99.9% broken-wall), β-nicotinamide mononucleotide (NMN), wild yellow ganoderma extract, wild green ganoderma extract, wild purple ganoderma extract, wild white ganoderma extract, wild black ganoderma extract
Specialist Clinical Centre for Teaching and Research, School of Chinese Medicine, The University of Hong Kong
Hong Kong, Hong Kong
RECRUITINGMean difference in Chalder Fatigue Score
Likert score 0-4 for 11 items, ranging 0-44, with higher scores indicating greater fatigue
Time frame: From baseline to 6 weeks
Mean difference in Chalder Fatigue Score
Likert score 0-4 for 11 items, ranging 0-44, with higher scores indicating greater fatigue
Time frame: From baseline to 12 weeks
Mean difference in 36-Item Short-Form Health Survey
ranging 0-100, with higher scores indicating better health status
Time frame: from baseline to 6 week and 12 week
Mean difference in Fatigue Severity Score
Likert score 1-7 for 9 items, ranging 9-63, where higher scores indicate more severe fatigue
Time frame: from baseline to 6 week and 12 week
mean difference in Patient Reported Outcome Measurement Information System (PROMIS) Fatigue-Short Form 7A survey
a 5-point Likert scale of 7 items, ranging 0-35, with higher scores indicating greater fatigue
Time frame: from baseline to 6 week and 12 week
Mean difference in hospital anxiety and depression scale
ranging 0-21, with higher scores indicating more severe symptoms
Time frame: from baseline to 6 week and 12 week
Mean difference in Pittsburgh sleep quality index
ranging 0-21, with higher scores indicating worse sleep quality
Time frame: from baseline to 6 week and 12 week visit.
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