Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

Lille University300 enrolled

Overview

The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

300

Conditions

Healthy

Interventions

ExerciseOTHER

Muscle induced-damage eccentric exercise

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female * Aged between 18 and 35 * Weighing more than 50 kg * Member of a sports club affiliated to an Olympic federation * Socially insured * Willing to comply with all study procedures and duration of the study Exclusion Criteria: * Medical history contraindicating sporting activities * Current medical treatment * Not a member of a sports club affiliated to an Olympic federation * Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.

Locations (1)

Eurasport

Loos, France

RECRUITING

Outcomes

Primary Outcomes

The association between single nucleotide polymorphisms and exercise induced blood creatine kinase variation

Association between blood creatine kinase level variations and single nucleotide polymorphisms. The Outcome Measure in this study is focused on the variation in plasma CPK levels following an exercise inducing muscle damage. The result is expressed as a change in plasma CPK concentration, measured in units per liter (U/L). This single measurement is used to investigate its association with genetic polymorphisms. Therefore a regression analysis will be performed to identify the association. This study is exploratory and the genetic polymorphisms are not pre-identified but will be investigated through a comprehensive analysis.

Time frame: Evolution of kinetics from Day 0 to Day 3 post experiment

Data from ClinicalTrials.gov

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