Evolution of the Relationship Between Central and Peripheral Arterial Wave Velocities as a Function of Age

N/ANot Yet RecruitingNCT06742775

University Hospital, Grenoble60 enrolled

Overview

Acquisition of synchronized cardiovascular signals from non-invasive measurements (ECG, photoplethysmography pulse sensors, inductance plethysmography) in healthy volunteers aged from 18 to 75, during spontaneous ventilation with apneas (20 seconds) for a total acquisition time of 30 minutes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aging Diagnostic Techniques, Cardiovascular

Interventions

physiological signal acquisitionsOTHER

Subjects will be fitted with non-intrusive devices. In a semi-recumbent position, they will be asked to perform * 10 minutes of resting breathing * 10 cycles consisting of a 20-second apnea, to be performed at the end of inspiration, and 1 minute 40 of breathing (100 seconds). This single participation session will last a total of one hour for the volunteer (equipment, recording, de-equipping), including 30 minutes of acquisition.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women between 18 and 75 years of age * No acute cardiovascular pathologies less than 2 years old, * No chronic cardiovascular pathologies. * Stature compatible with the use of the plethysmography T-shirt. * Person affiliated to a social security scheme or beneficiary of such a scheme * Signed informed consent form Exclusion Criteria: * Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons under psychiatric care under articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, persons under legal protection or unable to express their consent). * Personnel with a hierarchical link to the principal investigator * Subjects excluded from another study,

Locations (1)

Laboratoire TIMC

Grenoble, France

Outcomes

Primary Outcomes

Electrocardiogram

acquisition of ECG signals

Time frame: 1 hour

Photoplethysmography

acquisition of peripheral and central photoplethysmographic signals with radial, brachial, carotid and femoral sensors

Time frame: 1 hour

inductive plethysmography

acquisition of abdominal and thoracic section variations with an inductive plethysmographic vest

Time frame: 1 hour

Secondary Outcomes

link between peripheral and central pulse wave velocity

Assesment of the link between peripheral and central vascular function with statistical analysis (Linear regression, Bland and Altman test)

Time frame: 1 hour

Central Contacts

Stéphane TANGUY

CONTACT

+33476637117 stephane.tanguy@univ-grenoble-alpes.fr

Data from ClinicalTrials.gov

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