Metabolic Effects of the Exercise-metabolite Lac-Phe

University of Aarhus23 enrolled

Overview

The goal of this double-blinded, randomized cross-over clinical trial is to assess the isolated (i.e. outside the context of exercise) effects of Lac-Phe on appetite and glucose concentrations in healthy volunteers with obesity (BMI 28-35). The main questions it aims to answer are: * Does Lac-Phe reduce appetite in humans? * Does Lac-Phe have glucose-lowering properties in humans? During the study, participants will: * receive an intravenous infusion of Lac-Phe on one study day and a NaCl infusion on another study day. * drink a standard mixed meal * eat an ad libitum meal test * answer appetite questionnaires * indirect calorimetry * blood samples for hormone and substate analyses

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Healthy Overweight/Obese

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * A body mass index (BMI) between 28-35 kg/m2 * Older than 18 years of age * Hgb within a normal range (females: 7.3-9.5 mmol/L, males: 8.3-10.5 mmol/L) * Females can be included if they are either postmenopausal or actively use hormonal contraception (e.g., oral contraceptive pill or hormone-releasing intrauterine device). Exclusion Criteria: * Medications affecting glucose metabolism (e.g., Saxenda). * Anemia * Diabetes * Ongoing cancer or other acute/chronic serious diseases (PI will determine) * Inability to understand Danish or English * Deemed unsuitable to participate by the PI and co-investigators.

Outcomes

Primary Outcomes

ad libitum meal test

Meal intake (kcal) during the ad libitum meal test

Time frame: On the study day, from times 240 minutes and until meal completion as assessed by study participant