The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
30
Performs inspiratory maneuvers at 55% maximal inspiratory pressure (PIMAX) during week 1, 65% PIMAX during week 2, and 75% PIMAX during weeks 3-6.
Performs inspiratory maneuvers at 15% maximal inspiratory pressure (PIMAX) for all 6 weeks.
Inspiratory muscle training device
Mayo Clinic in Rochester
Rochester, Minnesota, United States
RECRUITINGChange in blood pressure
Measured in millimeters of mercury (mm Hg)
Time frame: Baseline, 6 weeks
Change in Muscle Sympathetic Nerve Activity (MSNA) burst frequency
Measured by microneurography reported in burst per minute
Time frame: Baseline, 6 weeks
Change in Muscle Sympathetic Nerve Activity (MSNA) burst incidence
Number of bursts recorded via microneurography
Time frame: Baseline, 6 weeks
Change in Hot Flash Frequency
Number of hot flashes indicated through self-reporting
Time frame: Baseline, 6 weeks
Chang in sleep duration
Measured by actigraphy data defined as recorded number of minutes in sleep
Time frame: Baseline, 6 weeks
Change in wake after sleep onset
Measured by actigraphy data defined as number of minutes from sleep onset to waking
Time frame: Baseline, 6 weeks
Change in Pittsburgh Sleep Quality Index
The Pittsburgh Sleep Quality Index measures the severity of sleep disturbances. Possible scores range from 0 to 21 with higher scores indicating a worse outcome/more severe symptoms of sleep disturbance.
Time frame: Baseline, 6 weeks
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