This trial hypothesized that novel laser refractive surgery techniques (LASIK, KLEx) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative stress generated by the surgical procedure. It is also intended to verify whether the new laser technology is necessary for clinical use in groups with low antioxidant activity through the detection of antioxidant activity in the eyes of patients.
Simultaneously measure total reactive oxygen species (ROS), antioxidant capacity (TAC) and ascorbic acid (AA) in aqueous humor (cataract surgery only) or tears. All patients underwent the same examination at our institution, including uncorrected visual acuity (UCVA), intraocular pressure (IOP), as well as central corneal thickness (CCT) with pneumatic tonometer, apparent refraction with autorefractor, and corneal curvature with keratometer. The axial length (AXL), anterior chamber depth (ACD) and lens thickness (LT) were measured by optical biometer.
Study Type
OBSERVATIONAL
Enrollment
1,000
Taipei Nobel Eye Clinic
Taipei, Taiwan
RECRUITINGChang Gung Memorial Hospital
Taoyuan District, Taiwan
RECRUITINGTAC in tears at 1 week
Change of Total Antioxidant Capacity (TAC) from Baseline to 1 week after surgery.
Time frame: Before the operation and 1 week after surgery.
TAC in tears at 1 month
Change of Total Antioxidant Capacity (TAC) from Baseline to 1 month after surgery.
Time frame: Before the operation and 1 month after surgery.
TAC in tears at 2 months
Change of Total Antioxidant Capacity (TAC) from Baseline to 2 months after surgery.
Time frame: Before the operation and 2 months after surgery.
TAC in tears at 3 months
Change of Total Antioxidant Capacity (TAC) from Baseline to 3 months after surgery.
Time frame: Before the operation and 3 months after surgery.
AA in tears at 1 week
Change of Ascorbic Acid (AA) from Baseline to 1 week after surgery.
Time frame: Before the operation and 1 week after surgery.
AA in tears at 1 month
Change of Ascorbic Acid (AA) from Baseline to 1 month after surgery.
Time frame: Before the operation and 1 month after surgery.
AA in tears at 2 months
Change of Ascorbic Acid (AA) from Baseline to 2 months after surgery.
Time frame: Before the operation and 2 months after surgery.
AA in tears at 3 months
Change of Ascorbic Acid (AA) from Baseline to 3 months after surgery.
Time frame: Before the operation and 3 months after surgery.
ROS in tears at 1 week
Change of Reactive Oxygen Species (ROS) from Baseline to 1 week after surgery.
Time frame: Before the operation and 1 week after surgery.
ROS in tears at 1 month
Change of Reactive Oxygen Species (ROS) from Baseline to 1 month after surgery.
Time frame: Before the operation and 1 month after surgery.
ROS in tears at 2 months
Change of Reactive Oxygen Species (ROS) from Baseline to 2 moths after surgery.
Time frame: Before the operation and 2 months after surgery.
ROS in tears at 3 months
Change of Reactive Oxygen Species (ROS) from Baseline to 3 months after surgery.
Time frame: Before the operation and 3 months after surgery.
TAC in aqueous humor at the next day
Change of Total Antioxidant Capacity (TAC) in aqueous humor from Baseline to one day after surgery
Time frame: Before the operation and one day after surgery.
AA in aqueous humor at the next day
Change of Ascorbic Acid (AA) in aqueous humor from Baseline to one day after surgery
Time frame: Before the operation and one day after surgery.
ROS in aqueous humor at the next day
Change of Reactive Oxygen Species (ROS) in aqueous humor from Baseline to one day after surgery
Time frame: Before the operation and one day after surgery.
BCVA
Examination of best corrected visual acuity (BCVA)
Time frame: Before surgery
UCVA at 1 week
Examination of uncorrected visual acuity (UCVA)
Time frame: 1 week after surgery
UCVA at 1 month
Examination of uncorrected visual acuity (UCVA)
Time frame: 1 month after surgery
UCVA at 2 months
Examination of uncorrected visual acuity (UCVA)
Time frame: 2 months after surgery
UCVA at 3 months
Examination of uncorrected visual acuity (UCVA)
Time frame: 3 months after surgery
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