Physiological Effects of APRVplus and TCAV in ARDS

West China Hospital20 enrolled

Overview

In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed. This study aims to compare the physiological effects of two types of APRV ventilation strategy, Early Pathophysiology-driven APRV (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV), through randomized crossover trials, providing evidence for clinical application and further research on APRV.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

ARDS (Acute Respiratory Distress Syndrome)

Interventions

APRVplusPROCEDURE

Early Pathophysiology-driven Airway Pressure Release Ventilation (APRVplus)

TCAVPROCEDURE

Time-Controlled Adaptive Ventilation (TCAV)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * intubated and mechanically ventilated patients * meet the 2023 global new definition of ARDS Exclusion Criteria: * Pregnancy * The expected duration of mechanical ventilation was less than 48 hours * Intracranial hypertension (suspected or confirmed) * Neuromuscular disorders that are known to prolong the need for mechanical ventilation * Known or suspected chronic obstructive pulmonary disease(COPD) * Terminal stage of disease * Pneumothorax (drained or not)at enrollment * Treatment with extracorporeal support (ECMO) at enrollment * There was a lack of commitment to life support

Locations (1)

West China Hospital, Sichuan University

Chengdu, Sichuan, China

Outcomes

Primary Outcomes

△PL（PLThigh - PLTlow)

Transpulmonary pressure swings (△PL) equal to PLThigh - PLTlow

Time frame: during the mechanical ventilation procedure

Secondary Outcomes

EtCO2

end-tidal carbon dioxide

Time frame: during the mechanical ventilation procedure

global inhomogeneity

Time frame: during the mechanical ventilation procedure

PaO2(mmHg)

the arterial partial pressure of oxygen

Time frame: during the mechanical ventilation procedure

Data from ClinicalTrials.gov

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