Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)?

Bakirkoy Dr. Sadi Konuk Research and Training Hospital1,000 enrolled

Overview

A Comparison of Ventilator Parameters (TV, DP, Total Mechanical Power, etc.) Between Successfully and unsuccessfully Weaned Patients with COPD Undergoing Mechanical Ventilation Due to Respiratory Failure, and Diagnosed with Pneumonia or ARDS in the Intensive Care Unit."

The objective of this study is to investigate which mechanical ventilation parameters and clinical findings influence weaning success by comparing successful and unsuccessful weaning patient groups among patients diagnosed with COPD who were intubated and monitored for more than five days in the intensive care unit. The findings of this study may contribute to the development of future treatment protocols and criteria for evaluating the weaning process. This study is planned to be conducted in two centers: Bakırköy Dr. Sadi Konuk Training and Research Hospital in Istanbul and Shahid Beheshti University of Medical Sciences, Masih Daneshvari Hospital in Tehran. This multicenter study aims to facilitate the comparison of data obtained under different geographical and clinical conditions, thereby enabling a broader analysis of factors influencing the weaning process across a larger patient population.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

COPD (Chronic Obstructive Pulmonary Disease)ARDS (Acute Respiratory Distress Syndrome)Mechanical Power Pneumonia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 years and older * COPD-diagnosed patients who have been intubated and stayed in the ICU for more than 5 days Exclusion Criteria: * Patients without electronic medical records * Patients under 18 years of age * Patients diagnosed with pulmonary malignancy * Patients who stayed in the ICU for less than 5 days * Patients monitored in the ICU without intubation

Outcomes

Primary Outcomes

Successful Weaning

The primary outcome of this study will be the successful weaning from mechanical ventilation. This will be defined as the patient being successfully extubated and maintaining adequate oxygenation for more than 48 hours without requiring reintubation or mechanical ventilation support.

Time frame: 48 hours

Secondary Outcomes

Mechanical Ventilator Parameters

A comparison of total mechanical power between the weaned and non-weaned patient groups.