Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty

Ankara Etlik City Hospital190 enrolled

Overview

The goal of this clinical trial is to find out the efficacy of diosmin and hesperidin on postoperative early rehabilitation after primary total knee arthroplasty. The main questions it aims to answer are: Does diosmin and hesperidin combined drug decreases the lower extremity swelling, pain and increases the range of motion after primary total knee arthroplasty surgery compared to standard therapy group? Does diosmin and hesperidin combined drug decreases inflammation after total knee arthroplasty surgery. Participants will take diosmin and hesperidin in addition to standard therapy for 14 days after total knee arthroplasty surgery. Lower extremity swelling, pain and range of motion of the patients will be recorded in every visit.

Study Type

OBSERVATIONAL

Enrollment

190

Conditions

Total Knee Arthroplasty Venous Insufficiency of Leg

Interventions

Diosmin and Hesperidin CombinationDRUG

Participants will take diosmin and hesperidin combination for 14 days after total knee replacement surgery.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who underwent unilateral primary total knee replacement surgery * Patients who are functionally ASA 1, ASA 2 or ASA 3. Exclusion Criteria: * Patients \>80 years or \<18 years of age * Patients with liver insufficiency * Patients with allergy to diosmin or hesperidin * Patients which are not capable to communicate

Locations (1)

Ankara Etlik City Hospital

Ankara, Yenimahalle, Turkey (Türkiye)

Outcomes

Primary Outcomes

Lower extremity swelling

Lower extremity swelling is measured by measuring extremity diameters from 3 points (below patella, patella and above patella) and noted. Then percentage of increment or decrement of diameters is measured.