This study is a multicenter, prospective, observational study aimed at investigating the efficacy and safety of triple targeted drug therapy in patients with arterial pulmonary hypertension (PAH) who are not at low risk and are receiving initial treatment. The prognosis of arterial pulmonary hypertension is explored.
Study Type
OBSERVATIONAL
Enrollment
48
Endothelin receptor antagonist (ERA) combined with PDE5i/sGC agonist dual therapy prostacyclin drugs Including macitentan sildenafil/tadalafil or riociguat selexipag/epoprostenol.
Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China
Jinan, Shandong, China
RECRUITINGPulmonary Vascular Resistance (PVR)
Time frame: Up to 3 months
N terminal pro B type natriuretic peptide (NT-proBNP)
Time frame: Up to 3 months
6-minute walking distance
Time frame: Up to 3 months
mean pulmonary arterial pressure (mPAP)
Time frame: Up to 3 months
cardiac index (CI)
Time frame: Up to 3 months
WHO Heart Function Classification
Time frame: Up to 3 months
Oxygen Saturation of Mixed Venose Blood (SvO2)
Time frame: Up to 3 months
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