Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters

Zhongshan Ophthalmic Center, Sun Yat-sen University500 enrolled

Overview

This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics. Explore whether it is possible to construct a clinical prediction model for liver transplantation by incorporating ocular biometric features, in order to optimize disease management before and after liver transplantation.

This study is a bidirectional cohort study, which retrospectively analysed data from a prospective database to construct a model, and prospectively collected patient information from preoperative to postoperative for model improvement and validation.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Diagnostic Techniques, Ophthalmological Liver Transplantation Liver Cirrhoses

Interventions

General Condition ExaminationDIAGNOSTIC_TEST

Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age greater than or equal to 18 years old; 2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis; 3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results; 4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters; 5. Voluntarily follow the clinical trial protocol and sign the informed consent form. Exclusion Criteria: 1. History of other organ transplant surgeries; 2. History of intraocular laser treatment, medication injection, and surgery; 3. History of high myopia, glaucoma, and retinal choroidal related eye diseases; 4. History of major systemic diseases other than liver disease; 5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.

Outcomes

Primary Outcomes

The performance of predicting the prognosis of liver transplantation

Based on the outcomes of early graft dysfunction and 1-year graft survival rate, the area under the receiver operating characteristic curve, specificity, and sensitivity of the model

Time frame: 1 week and 1 year after liver transplantation

Secondary Outcomes

The performance of the model in assessing the severity of liver disease

The confusion matrix of the model based on the MELD score results

Time frame: 1 year