Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation

Sohag University100 enrolled

Overview

This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy. We compare between 2 combinations as regard hemodynamic stability, post operative side effects as occurrence of delirium, nausea, vomiting, headache, hallucination or agitation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

100

Conditions

Propofol

Interventions

Dexmedetomidine-PropofolDRUG

efficacy of sedation with Dexmedetomidine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Ketamine-PropofolDRUG

efficacy of sedation with Ketamine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists physical status I to II. * Age between 18 and 60 years. * Both sexes. Exclusion Criteria: * Having severe heart, lung, liver disease, kidney failure, or bleeding disorder. * Patients having fever, hypothermia or infection, electrolyte disorders, such as hypokalemia and hypocalcaemia, acid-base disorder, allergy to drugs to be used.

Locations (1)

Sohag University Hospital

Sohag, Egypt

RECRUITING

Outcomes

Primary Outcomes

intraoperative and postoperative monitoring of sedation during upper or lower gastrointestinal system endoscopy.

Sedation level

Time frame: every 5 minutes intraoperative and every 15 minutes for 2 hours postoperative.

Central Contacts

Ahmed H Hamed, Resident

CONTACT

01124623298 Ahmedh9996@yahoo.com

Alhaddad A Mosa, Professor

CONTACT

01019816967

Data from ClinicalTrials.gov

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