Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in COPD patients.
The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. These comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. Addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of COPD. According to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. Blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to COPD rehabilitation. The research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with COPD. The findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of COPD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
90
The aerobic exercise intervention will utilize an ergometer. The program will be conducted 2-3 times per week over a 3-month period.
The participants will be provided by educational program about COPD self-care and home-based exercise approach.
Blood flow restriction (BFR) intervention will combine aerobic exercise on the ergometer with BFR training. The program will be conducted 2-3 times per week over a 3-month period.
National Cheng Kung University Hostipal
Tainan, Taiwan, Taiwan
RECRUITINGOxygen consumption (VO2)
Oxygen consumption examined by cardiopulmonary exercise test
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Diaphragm capacity
Diaphragm capacity examined by diaphragmatic ultrasound
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Functional capacity
Functional capacity examined by 6MWT
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Heart Rate Variability
Heart Rate Variability examined by autonomic nervous system
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Pulmonary function test
Pulmonary function test examined by spirometer. Spirometry is a physiological test that measures the ability to inhale and exhale air over time. The main spirometry results are forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and the FEV1/FVC ratio.
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Maximum respiratory pressure
Maximum respiratory pressure examined by pressure meter
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Quality of life score (COPD-related questionnaire-I)
Quality of life score examined by mMRC Questionnaire.
Time frame: Change from baseline (0 week) to follow up (20 weeks)
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Quality of life score (COPD-related questionnaire-II)
COPD Assessment Test (CAT) questionaire
Time frame: Change from baseline (0 week) to follow up (20 weeks)
Quality of life score (COPD-related questionnaire-III)
St George's Respiratory Questionnaire (SGRQ)
Time frame: Change from baseline (0 week) to follow up (20 weeks)