Efficacy of Aleo Vera Use in Prevention and Treatment of Chemotherapy-Induced Oral Mucositis in a Group of Egyptian Children with Acute Leukemia

Ain Shams University40 enrolled

Overview

evaluatation the efficacy of Aleovera in prevention and treatment of chemotherapy-induced oral mucositis in children suffering from acute leukemia in terms of appearance and severity

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Oral Mucositis

Interventions

Second arm: Using aleovera for Prevention and Treatment of Chemotherapy-Induced Oral MucositisOTHER

Second arm : aleovera 3 times daily after brushing teeth

Eligibility

Sex: ALLMin age: 3 YearsMax age: 13 Years

Medical Language ↔ Plain English

Inclusion criteria 1. Patients suffering from Acute leukemia( Acute Lymphocytic Leukemia ). 2. Patients scheduled for chemotherapy treatment. 3. Patients who range from 3 to 13 years old. 4. Patients with no history of any chemotherapy or radiotherapy. 5 -Both sexes Exclusion Criteria 1-Patients scheduled for radiotherapy treatment . 2-Existence of any signs or symptoms of oral mucositis. 3-Unwilling to participation in the study 4- Patients with any other systemic diseases or other neoplasms.

Locations (1)

Faculty of dentistry

Cairo, Egypt

Outcomes

Primary Outcomes

Prevention of oral mucositis

Assessment the efficacy of aleo vera gel on prevention of chemotherapy-induced oral mucositis through application the gel 3 times daily then patients were assessed daily in terms of appearance and severity of oral mucositis according WHO grading system. The World Health Organization (WHO) mucositis scale is used to grade the severity of oral mucositis. Grade 0: No mucositis Grade 1: Soreness/erythema only. Grade 2: Erythema, and ulcers. Able to tolerate solids. Grade 3: Unable to tolerate solids but able to tolerate liquids. Grade 4: Unable to tolerate solids or liquids. Oral alimentation is not possible.

Time frame: 2 months

Data from ClinicalTrials.gov

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