Assessment of Corneal Topography and Densitometry in Rheumatoid Patients

Sohag University40 enrolled

Overview

Corneal transparency is a result of its unique ultrastructure with collagen fibrils regularity, integrity of connective tissue, and balanced keratocyte components. Corneal densitometry is known to be altered in cases corneal haze or scar, but recently it is assumed to be altered earlies in presence of a systemic inflammatory disease, even before clinical manifestations take place. The aim of this study is to assess changes in corneal topography and corneal densitometry in RA patients with clinically clear corneas and to compare these results with those of healthy control subjects.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cornea

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with rheumatoid arthritis Exclusion Criteria: * corneal opacity; severe dry eye; glaucoma; any inflammatory ocular disorder or infection including blepharitis, conjunctivitis, meibomitis and dacryocystitis; central or peripheral thinning evident in slit-lamp examination; history of ocular surgery, trauma, or contact lens use; and patients using any topical medication other than artificial tears will be excluded from the study.

Locations (2)

Amr Mounir

Sohag, Egypt

Elshimaa A.Mateen

Sohag, Egypt

Outcomes

Primary Outcomes

Corneal topographic changes and densitometry in patients with rheumatoid arthritis

Time frame: one year

Data from ClinicalTrials.gov

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