Study design: It is a monocentric and exploratory study, experimental on human tissues in vitro which involves the analysis of peripheral blood in patients with Hodgkin's lymphomas with the following characteristics: * in complete remission for at least two years after first-line therapy with stage IIb, III or IV at onset (Ann Arbor classification). * newly diagnosed (stage IIb, III or IV, Ann Arbor Classification).
The study aims to evaluate patients with hodgkin lymphoma in complete remission for at least 2 years and newly diagnosed (stage II b, stage III or stage IV) as they are currently characterised by a long life expectancy during which there is an increased and early incidence of non-neoplastic systemic complications as well as, of course, manifestations of secondary malignancies.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
200
It is a monocentric and exploratory study, experimental on human tissues in vitro and similar projects do not exist in the literature. This study involves the analysis of peripheral blood in patients with hodgkin lymphoma with the following characteristics: * in complete remission for at least two years after first-line therapy with stage II b, III or IV at onset (Ann Arbor classification). * newly diagnosed (stage II b, III or IV, Ann Arbor Classification).
IRCCS Azienda Ospedaliero - Universitaria di Bologna
Bologna, Italy
RECRUITINGevaluation of senescence markers (CD57, KLRG1,CD62L, CD45RA)
Determine the biological age of patients
Time frame: through study completion, an average of 2 year
DNA methylation (methylation rate)
Determine the biological age of patients
Time frame: through study completion, an average of 2 year
evaluation of senescence markers (CD57, KLRG1,CD62L, CD45RA)
Determine the possible acceleration of the biological age of patients
Time frame: through study completion, an average of 2 year
DNA methylation (methylation rate)
Determine the possible acceleration of the biological age of patients
Time frame: through study completion, an average of 2 year
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