To Evaluate the Safety and Efficacy of Pediococcus Acidilactici PA53 in Relieving Constipation in Adults

Inclusion Criteria: 1\. Constipated subjects Subjects (less than 3 bowel movements per week and/or Bristol Scale Types 1 and 2); 2. Be able to complete the research according to the requirements of the test plan; 3. Subjects who have signed informed consent; 4. Subjects (including male subjects) have no family planning and voluntarily take effective contraceptive measures from 14 days before screening to 6 months after the end of the trial. \- Exclusion Criteria: 1. Short-term use of items with similar functions to the subject, which affects the judge of the result; 2. Those who changed their diet type during the study period; 3. People with severe allergies and immune deficiencies; 4. Women who are pregnant, breastfeeding or planning to become pregnant; 5. Patients with serious diseases of cardiovascular, lung, liver, kidney and other vital organs, diabetes, thyroid disease, severe metabolic diseases, malignant tumors, and severe immune system diseases; 6. People who have used antibiotics in the past two weeks; 7. People with serious mental and mental illness; 8. Failure to eat the test sample as required, or failure to follow up on time, resulting in uncertain efficacy; 9. Other researchers judged it inappropriate to participate. -