Molecular and Microbiota Signatures Underlying Colonic Diverticular Disease

N/AActive Not RecruitingNCT06764550

IRCCS Azienda Ospedaliero-Universitaria di Bologna150 enrolled

Overview

The pathogenesis of diverticular disease is likely multifactorial in origin. This project aims to study the involvement of environmental factors in the pathophysiology of diverticular disease, the underlying molecular mechanisms, and alterations in the microbiota.

The pathogenesis of diverticular disease is likely multifactorial in origin. Some studies have demonstrated the role of genetic factors, while others have highlighted the role of environmental factors. The present project aims to study the involvement of environmental factors in the pathophysiology of diverticular disease, the underlying molecular mechanisms, and alterations in the microbiota.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Diverticular Disease of Colon

Interventions

This is an observational study, participants are not assigned an intervention as part of the study.OTHER

This is an observational study, participants are not assigned an intervention as part of the study.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 18 and 75 years. * Belonging to one of the following groups: 1. Patients with diverticula of the colon without symptoms. 2. Patients symptomatic for diverticular disease. 3. Subjects undergoing colonoscopy for colorectal cancer prevention or follow-up of previous polypectomies, asymptomatic for digestive symptoms. * Obtaining informed consent. Exclusion Criteria: * Acute complicated diverticulitis (bleeding, perforation) * Previous colon surgery * Antibiotics or laxatives within the past 90 days * Pregnancy and/or lactation * Systemic and psychiatric disorders * Asthma, food allergies and other allergic-type disorders * Possible diseases leading to intestinal bacterial contamination (diabetes, blind loop syndrome, rheumatologic diseases).

Locations (1)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, Italy

Outcomes

Primary Outcomes

Assess the interaction between host factors and gut microbiota

Time frame: 3 years

Data from ClinicalTrials.gov

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