Impact of Refractory Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise

Inclusion Criteria: * Age \>18 years * Chronic cough as per European Respiratory Society definition (\>8 weeks duration) * High symptom burden (i.e., cough visual analogue scale \>40 mm at pre-study screening) * Chest radiograph or CT within 3 years of the screening visit with no abnormalities considered to contribute to chronic cough Exclusion Criteria: * Smokers or individuals who gave up smoking within 12 months * Smoking history \>20 pack-years * Long-COVID or post-COVID syndrome (defined as symptoms lasting over 12-weeks in duration) * Recent exacerbation of cough within 4 weeks of inclusion * Respiratory tract infection within 4 weeks of inclusion * Currently taking any of the following medications: * ACE inhibitors and within 3 months of inclusion * Antitussives (opioids, pregabalin, gabapentin, amitriptyline, nortriptyline, or over the-counter medications) within 2 weeks of inclusion * Medical treatments for gastro-oesophageal reflux disease (GORD), eosinophilic bronchitis or other cough related conditions, initiated or changed (i.e., not in a stable regimen) for 4 weeks prior to inclusion * Medical history of asthma or exercise-induced bronchoconstriction (EIB), COPD, or chronic bronchitis in the judgement of the investigator * Medical conditions/history or other circumstances which, in the judgement of the investigators, could increase the risk of adverse events or bias the study results