Comparison of the Incidence of Delirium Caused by Different Anesthetic Agents in Patients Undergoing Liver Transplantation

Yonsei University350 enrolled

Overview

This study is a prospective observational study that analyzes the incidence of postoperative delirium in patients undergoing liver transplantation, based on the use of the inhalational anesthetic sevoflurane and the intravenous anesthetic propofol.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Hepatocellular Carcinoma Liver Cirrhosis

Eligibility

Sex: ALLMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 19 years and older * Patients undergoing liver transplantation who are scheduled to receive anesthesia with the inhaled anesthetic sevoflurane or the intravenous anesthetic propofol. Exclusion Criteria: * Individuals with hearing loss, cognitive impairment or obvious dementia, hepatic encephalopathy, or difficulty in communication. * Diagnosed with neurological disorders (e.g., brain hemorrhage, stroke, dementia, Parkinson's disease, cognitive impairment, etc.).

Locations (1)

Department of Anesthesiology and Pain Medicine Yonsei University College of Medicine

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

incidence of postoperative delirium

At least two times a day during the hospitalization period. Patients diagnosed with delirium using the CAM were evaluated for the duration, symptoms, and type of delirium (e.g., reduced awareness of the environment; poor cognitive skills; behavioral changes; and emotional disturbances). \*\* Confusion assessment methods(CAM) diagnostic algorism (positive or negative result, positive means delirium) CAM is considered positive if features 1 and 2 are present, with at least one of features 3 or 4. Below are the four criteria of features : 1. Acute onset and fluctuating course Determined by collateral history or repeated clinic assessment 2. Inattention Counting from 20-1 is a simple (if blunt) test for this 3. Disorganized thinking 4. Altered levels of consciousness

Time frame: from postoperative day 0 to postoperative day 7

Secondary Outcomes

comprehensive geriatric assessment(CGA)

Core component of CGA are as follows : The Korean version of the fatigue, resistance, ambulation, illnesses, and loss of weight (K-FRAIL) scale : 0(healthy)\~8(frail) Mini Nutritional Assessment(MNA) : 0 (malnutrition)\~14(normal) Geriatric Depression Scale(GDS) : 0(normal)\~ 15(depression) Instrumental Activities of Daily Living(IADL)-Lawton-Brody Scale : 0\~8(complete independence)

Time frame: Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks

duration of delirium

Duration of Delirium: The duration of delirium is measured from the onset to the resolution of symptoms, recorded in hours or days (e.g., 1 day, 3 days, 5 days).

Time frame: Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks

total score of QOR-40

The Quality of Recovery-40 (QoR-40) 40\~200(better recovery)

Time frame: Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks

Data from ClinicalTrials.gov

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