Association Between GalectiN-3 and POSt-operative AtrIal Fibrillation After Coronary Artery BypaSs Graft

University of Sao Paulo General Hospital90 enrolled

Overview

The goal of this observational study is to test the association between high levels of Galectin-3 and the occurrence of post-operative atrial fibrillation after isolated coronary artery bypass grafting (CABG). The main question\[s\] it aims to answer are: * Is Galectin-3 an accurate biomarker to predict higher risk of developing post-operative atrial fibrillation? * Are high levels of Galectin-3 associated to other post-operative complications and major adverse cardiovascular events? Participants will be enrolled during pre-operative evaluation and a peripheral blood sample collection will be performed in the 24h before CABG. Participants will then be followed for a period of 12 months (daily during hospitalization and 3 appointments after hospital discharge) to determine whether patients with higher levels of Galectin-3 will have worse outcomes.

Prospective, observational, single-center cohort study including patients undergoing coronary artery bypass graft (CABG) surgery. Patients will be enrolled during preoperative evaluation. A peripheral blood sample will be collected within 24 hours before surgery and patients will be followed during hospitalization and for 12 months after discharge.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Post-operative Atrial Fibrillation Cardiovascular Diseases Post-pericardiotomy Syndrome

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing coronary artery bypass graft surgery Exclusion Criteria: * Inability to sign the free and informed consent form * Renal dysfunction with estimated glomerular filtration rate less than 30ml / min / 1.73m² or dialysis therapy * Moderate to severe left ventricular dysfunction (ejection fraction \< 40%) * Patients with previous atrial fibrillation * Pregnancy * Concomitant valve surgery

Outcomes

Primary Outcomes

Galectin-3 and post-operative atrial fibrillation

Evaluate the association of higher levels of Galectin-3 (in ng/mL) and the occurrence of post-operative atrial fibrillation lasting at least 12 hours or requiring cardioversion

Time frame: Up to 7 days after surgery

Secondary Outcomes

Galectin-3 and other post-operative complications

Evaluate the association of higher levels of Galectin-3 (in ng/mL) and the occurrence of post-operative complications, such as infection, bleeding, post-pericardiotomy syndrome, reoperation, systemic embolism, type 5 myocardial infarction

Time frame: 6 weeks

Galectin-3 and major adverse cardiovascular events

Evaluate the association of higher levels of Galectin-3 (in ng/mL) and the occurrence major adverse cardiovascular events, such as stroke, acute coronary syndrome, revascularization procedures and cardiovascular death

Time frame: 12 months

Galectin-3 and left atrial remodeling

Evaluate the association of higher levels of Galectin-3 (in ng/mL) and left atrial enlargement (both linear and volumetric echocardiographic measurements) and development of supraventricular arrhythmias in holter monitoring