Crohn's disease, a chronic inflammation of the gastro-intestinal tract, is a disease with a complex pathogenetic background. Hereditary factors, environmental factors and the gut flora play a varying role in its onset, however, this role remains unclear to date. We hypothesize to detect tiny fragments of microbial DNA from the gut in the bloodstream, due to disruption in the natural defences of the gut lining. If this is true, it may hold the key to understanding why Crohn's disease recurs after surgery. Our objective in this study is to test retrospectively, if we can detect any difference in microbial DNA from the blood of ileocolonic resection (ICR) patients that do and do not show recurrence at the time of follow-up endoscopy at 6 months.
Study Type
OBSERVATIONAL
Enrollment
70
Erasmus Medical Center
Rotterdam, South Holland, Netherlands
Differences in bloodmicrobiome between recurrence & non recurrence patients.
To test retrospectively, if we can detect any difference in microbial DNA from the blood of ICR patients that do and do not show recurrence, defined as a Rutgeerts score ≥ i2b at the time of follow-up endoscopy at 6 months.
Time frame: From enrollment to the postoperative endoscopy (at 6 months follow-up).
o To identify blood biomarkers predicting postoperative recurrence in Crohn's disease.
Time frame: From enrollment to the postoperative endoscopy (at 6 months follow-up).
o To identify histological parameters predicting postoperative recurrence in Crohn's disease.
Time frame: From enrollment to the postoperative endoscopy (at 6 months follow-up).
o To correlate blood biomarkers with fecal biomarkers predicting postoperative recurrence in Crohn's disease.
Time frame: From enrollment to the postoperative endoscopy (at 6 months follow-up).
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