Background: Breast cancer is the most common malignancy among women worldwide, with breast-conserving surgery (BCS) being a key treatment. The modified 5-item frailty index (mFI-5), a well-validated tool for assessing frailty, has shown predictive utility in other surgical contexts but remains under-explored in BCS. Methods: Using the American College of Surgeons National Surgical Quality Improvement Program database (2008-2021), the investigators identified adult female breast cancer patients who underwent BCS. Frailty was assessed using the mFI-5, scored from 0 to 5, with higher scores indicating greater frailty. Multivariable logistic regression was employed to evaluate associations between mFI-5 scores and postoperative outcomes. Main question: Can the mFI-5 predict adverse postoperative outcomes in breast-conserving surgery patients?
Study Type
OBSERVATIONAL
Enrollment
96,586
Technische Universität München
Munich, Bavaria, Germany
General data
* Hospital length of stay (in days). * Operative time (in minutes).
Time frame: 30 days
Any complications
* Patient mortality. * (Unplanned) readmission. * Surgical and/or medical complications.
Time frame: 30 days
Surgical Complications
* Infections (superficial, deep, or organ-space). * Wound dehiscence. * Bleeding requiring transfusion.
Time frame: 30 days
Medical Complications
* Pneumonia. * Reintubation. * Pulmonary embolism. * Ventilator dependence \>48 hours. * Progressive renal insufficiency. * Urinary tract infection. * Stroke or cerebrovascular accident. * Myocardial infarction. * Deep vein thrombosis or thrombophlebitis. * Sepsis. * Septic shock.
Time frame: 30 days
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