Efficacy Evaluation of Avance QQ Collagen for Skin Beautification

Inclusion Criteria: * Healthy male or female adults, age above 18 years old; * The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023)); * Commitment not to use products having activity comparable with that of the product to be tested during the study period; * Free of any dermatological or systemic disorder that would interfere with results. Exclusion Criteria: * Subject with obvious skin surface damage; * Subject who had oral or topical medication which may affect skin condition within 1 month; * Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product; * Female who is pregnant, nursing or planning to become pregnant during the course of the study; * Received facial laser therapy, chemical peeling in the past 2 months.