This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Folic Acid 1mg per day
Vitamin B6, 25mg per day
Vitamin B12, 1,000 ug per day
Oregon Health & Science University (OHSU)
Portland, Oregon, United States
RECRUITINGHyperhomocysteinemia and B vitamin deficiency
Plasma vitamin B12 in subjects with vs without hyperhomocysteinemia
Time frame: baseline measurement
Hyperhomocysteinemia and B vitamin deficiency
Plasma folic acid in subjects with vs without hyperhomocysteinemia
Time frame: baseline measurement
Hyperhomocysteinemia and B vitamin deficiency
Plasma pyridoxine in subjects with vs without hyperhomocysteinemia
Time frame: baseline measurement
Hyperhomocysteinemia and cognitive assessments
Change in total Braincheck score in subjects with vs without hyperhomocysteinemia
Time frame: From enrollment to the end of treatment at 3 months
Hyperhomocysteinemia and measurement of neurofilament light in plasma
Change in plasma neurofilament level in subjects with vs without hyperhomocysteinemia
Time frame: From enrollment to the end of treatment at 3 months
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